protein

IL-36 alpha/IL-1F6 Protein, Mouse

HY-P72547

2 μg;10 μg;20 μg;50 μg;100 μg;500 μg;1 mg

32;82;130;250;425;1200;1750 USD

IL-36 alpha/IL-1F6 Protein, Mouse

proteins

E. coli

2 μg;10 μg;20 μg;50 μg;100 μg;500 μg;1 mg

32;82;130;250;425;1200;1750 USD

IL-36 alpha (IL-1F6), a subform of IL-36 family, belongs to IL-1 superfamily. IL-36 alpha mediates inflammatory response. IL-36 alpha binds to IL-36R and activates NF-κB and MAPK signaling pathways, but the activation requires N-terminal cleavage by neutrophil granule-derived proteases [1] . IL-36 alpha also binds to IL-1Rrp2 and recruit IL-1RAcP. IL-36 alpha activats the MAPK, Erk1/2 and JNK through IL-36R/IL-1RAcP [2] . IL-36 alpha/IL-1F6 Protein, Mouse is a recombinant mouse IL-36 alpha without any tag, which is produced in E. coli.

Mouse

IL-36 alpha, a subform of IL-36 family, belongs to IL-1 superfamily. IL-36 alpha is expressed in monocytes, T/B-lymphocytes, spleen, bone-marrow tonsils, lymph nodes and skin [2] . The sequence of amino acids in IL-36 alpha differs in different species. Human IL-36 alpha shares IL-36 alpha binds to IL-36R and activates NF-κB and MAPK signaling pathways, thereby mediating inflammatory response. But the activation requires N-terminal cleavage by neutrophil granule-derived proteases, such as cathepsin G, elastase and proteinase-3 [1] . IL-36 alpha can also bind IL-1Rrp2 and recruit IL-1RAcP. IL-36 alpha activats the MAPK, Erk1/2 and JNK through IL-36R/IL-1RAcP [2] . IL-36α is significantly increased after infection. IL-36 alpha plays a key role in regulating antibacterial function of macrophages, which is required for the protection against sepsis in mice [3] . IL-36 alpha is a proinflammatory factor in the immune response of fungal keratitis, and promotes the corneal inflammation [4 IL-36 alpha is a pro-inflammatory cytokine associated with some infectious and immune diseases. IL-36 alpha mediates inflammatory response through the activation of NF-κB and MAPK signaling pathway [1] .

Interleukin-36 alpha; IL-36A; IL-1 epsilon; IL-1F6; IL-1H1

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4 or PBS, pH 7.4, 8% trehalose, 8% mannitol and 0.02% Tween80.

Room temperature in continental US; may vary elsewhere.