protein

IL-36 beta/IL-1F8 Protein, Mouse

HY-P72546

10 μg;50 μg

128;352 USD

IL-36 beta/IL-1F8 Protein, Mouse

proteins

E. coli

10 μg;50 μg

128;352 USD

IL-36 beta (IL-1F8), a subform of IL-36 family, belongs to IL-1 superfamily. IL-36 beta mediates inflammatory response. L-36 beta binds to IL-36R and recruits the co-receptor IL-1RacP, and thereby activating NF-κB and MAPK signaling pathways, but the activation requires N-terminal cleavage by neutrophil granule-derived proteases [1] [2] . IL-36 beta/IL-1F8 Protein, Mouse is a recombinant mouse IL-36 beta without any tag, which is produced in E. coli.

Mouse

IL-36 beta, a subform of IL-36 family, belongs to IL-1 superfamily. IL-36 beta is expressed in monocytes, T/B-lymphocytes, bone-marrow, tonsils, heart, lung, testis, colon, neuron cells, glial cells [3] . The sequence of amino acids in IL-36 beta differs in different species. Mouse IL-36 beta shares L-36 beta binds to IL-36R and recruits the co-receptor IL-1RAcP. So that the heterodimeric signaling complex brings Toll/IL-1R (TIR) domains of the 2 receptor chains in close proximity, and thereby activating NF-κB and MAPK signaling pathways [1] . But the activation requires N-terminal cleavage at Arg5 by neutrophil granule-derived proteases, such as cathepsin G, elastase and proteinase-3 [2] . IL-36β plays a role in the pathogenesis of inflammatory diseases, such as intestinal inflammation [4] . IL-36 beta is a pro-inflammatory factor. IL-36 beta mediates inflammatory response through the activation of NF-κB and MAPK signaling pathway [2] .

Interleukin-36 beta; FIL1 eta; IL-1 eta; IL-1F8; IL-1H2; IL36B

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized from a 0.2 μm filtered solution of 20 mM Tris,150 mM NaCl,1 mM EDTA, pH 8.0.

Room temperature in continental US; may vary elsewhere.