protein

IL-36 gamma/IL-1F9 Protein, Mouse

HY-P72544

2 μg;10 μg;50 μg;100 μg

77;200;480;816 USD

IL-36 gamma/IL-1F9 Protein, Mouse

proteins

E. coli

2 μg;10 μg;50 μg;100 μg

77;200;480;816 USD

IL-36 gamma (IL-1F9), a subform of IL-36 family, belongs to IL-1 superfamily. IL-36 gamma mediates inflammatory response. L-36 beta binds to IL-36R and recruits the co-receptor IL-1RacP, and thereby activating NF-κB and MAPK signaling pathways, but the activation requires N-terminal cleavage by neutrophil granule-derived proteases [1] [2] . IL-36 gamma/IL-1F9 Protein, Mouse is a recombinant mouse IL-36 gamma (G13-S164) without any tag, which is produced in E. coli.

Mouse

IL-36 gamma (IL-1F9), a subform of IL-36 family, belongs to IL-1 superfamily. IL-36 gamma is expressed in peripheral blood lymphocytes, keratinocytes, bronchial epithelial cells and THP-1 cells [3] . The sequence of amino acids in IL-36 gamma differs in different species. Human IL-36 gamma shares IL-36 gamma has β-trefoil structure. L-36 gamma binds to IL-36R and recruits the co-receptor IL-1RAcP. So that heterodimeric signaling complex brings Toll/IL-1R (TIR) domains of the 2 receptor chains in close proximity, and thereby activating NF-κB and MAPK signaling pathways [1] . But the activation requires N-terminal cleavage at Val15 18 by neutrophil granule-derived proteases, such as cathepsin G, elastase and proteinase-3 [1] [2] . IL-36 gamma is an effective type I and IL-17-mediated immunity against bacterial lung infection [4] . IL-36 gamma also mediates immune protection during influenza infection in mice [5] . IL-36 gamma is a pro-inflammatory factor. IL-36 gamma mediates inflammatory response through the activation of NF-κB and MAPK signaling pathway [2] .

Interleukin-36 gamma; IL-36γ; IL36G; IL-1F9; IL-1H1

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized from a 0.2 μm filtered solution of 20 mM MOPS, 10 mM TCEP, 150 mM NaCl, pH 7.4.

Room temperature in continental US; may vary elsewhere.