protein

ITGA5 Protein, Human (HEK293, His)

HY-P72533

10 μg;50 μg

115;300 USD

ITGA5 Protein, Human (HEK293, His)

proteins

HEK293

10 μg;50 μg

115;300 USD

ITGA5 is a multifunctional receptor that interacts with multiple ligands such as fibronectin, fibrinogen, PLA2G2A, fibrillin-1 (FBN1), IL1B, human metapneumovirus, and soluble CD40LG. ITGA5 recognizes RGD sequences and mediates cell adhesion through different binding sites. ITGA5 Protein, Human (HEK293, His) is the recombinant human-derived ITGA5 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of ITGA5 Protein, Human (HEK293, His) is 954 a.a., with molecular weight of ~130 kDa.

Human

The Integrin alpha-5/beta-1 protein (ITGA5:ITGB1) functions as a versatile receptor with diverse ligand interactions. Recognizing the R-G-D sequence in its ligands, ITGA5:ITGB1 serves as a receptor for fibronectin and fibrinogen, mediating cell adhesion through distinct binding sites. Notably, it binds to PLA2G2A at a site separate from its classical ligand-binding site, inducing conformational changes that enhance ligand binding. Additionally, ITGA5:ITGB1 acts as a receptor for fibrillin-1 (FBN1), facilitating R-G-D-dependent cell adhesion. It is also a receptor for fibronectin (FN1), enabling R-G-D-dependent cell adhesion to FN1. Furthermore, ITGA5:ITGB1 serves as a receptor for IL1B, playing a crucial role in IL1B signaling. In the context of microbial infection, ITGA5:ITGB1 acts as a receptor for Human metapneumovirus, highlighting its involvement in pathogen recognition. Moreover, ITGA5:ITGB3 acts as a receptor for soluble CD40LG, playing a vital role in CD40/CD40LG signaling. This broad spectrum of ligand interactions underscores the multifunctionality of ITGA5:ITGB1 in cellular processes and signaling pathways.

Integrin Alpha-5; Fibronectin Receptor Subunit Alpha; Integrin Alpha-F; VLA-5; CD49e; ITGA5; FNRA

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized from a 0.2 μm filtered solution of 20 mM PB, 150 mM NaCl, pH 7.2.

Room temperature in continental US; may vary elsewhere.