protein

LAMP2/CD107b Protein, Human (HEK293, His)

HY-P72525

10 μg;50 μg

70;190 USD

LAMP2/CD107b Protein, Human (HEK293, His)

proteins

HEK293

10 μg;50 μg

70;190 USD

LAMP2 is a key lysosomal glycoprotein that plays crucial roles in lysosomal biogenesis, pH regulation, and autophagy. It directly inhibits the TMEM175 proton channel, optimizing lysosomal acidity for efficient hydrolase activity. LAMP2/CD107b Protein, Human (HEK293, His) is the recombinant human-derived LAMP2/CD107b protein, expressed by HEK293 , with C-6*His labeled tag.

Human

LAMP2, a lysosomal membrane glycoprotein, assumes a pivotal role in lysosome biogenesis, lysosomal pH regulation, and autophagy. It acts as a crucial regulator of lysosomal lumen pH by directly inhibiting the proton channel TMEM175, facilitating optimal lysosomal acidification for effective hydrolase activity. LAMP2 plays a significant role in chaperone-mediated autophagy, participating in the lysosomal degradation of proteins during various stresses and as part of the normal turnover of long-lived proteins. This function involves binding target proteins such as GAPDH, NLRP3, and MLLT11 and directing them for lysosomal degradation. In chaperone-mediated autophagy, LAMP2 operates downstream of chaperones like HSPA8/HSC70, which recognize and bind substrate proteins, mediating their recruitment to lysosomes where LAMP2 facilitates binding. Furthermore, LAMP2 is essential for the fusion of autophagosomes with lysosomes during autophagy, influencing the degradation of autophagosomal contents. Additionally, LAMP2 is required for the efficient presentation of exogenous antigens via MHCII-mediated pathways, as it modulates chaperone-mediated autophagy and decreases the presentation of endogenous antigens by MHCII, highlighting its multifaceted roles in cellular processes.

Lysosome-Associated Membrane Glycoprotein 2; LAMP-2; CD107 Antigen-Like Family Member B; CD107b

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized from a 0.2 μm filtered solution of 20 mM PB, 150 mM NaCl, pH 7.2.

Room temperature in continental US; may vary elsewhere.