protein

TIM-3/HAVCR2 Protein, Marmoset (HEK293, His)

HY-P72510

10 μg;50 μg

125;285 USD

TIM-3/HAVCR2 Protein, Marmoset (HEK293, His)

proteins

HEK293

10 μg;50 μg

125;285 USD

TIM-3/HAVCR2 Protein is a transmembrane glycoprotein of the TIM family of immune regulating molecules and plays an important role in the Th1-mediated immune response [1] . TIM-3/HAVCR2 Protein, Marmoset (HEK293, His) is the recombinant Marmoset-derived TIM-3/HAVCR2 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of TIM-3/HAVCR2 Protein, Marmoset (HEK293, His) is 170 a.a., with molecular weight of 30-45 kDa.

Marmoset

TIM-3/HAVCR2 Protein is a transmembrane protein of T lymphocytes (CD4 + and CD8 + T cells), other lymphocytes (like NK cells), myeloid cells (monocytes, macrophages, DC, mast cells), or various cells in different tumor types. TIM-3/HAVCR2 Protein is an immune checkpoint and together with other inhibitory receptors including programmed cell death protein 1 (PD-1) and lymphocyte activation gene 3 protein ( LAG3 ) mediate the CD8+ T-cell exhaustion in terms of proliferation and secretion of cytokines such as TNF-alpha, IFN-gamma and IL-2 [2] [3] .TIM-3/HAVCR2 Protein has also been shown as a CD4+ Th1-specific cell surface protein that regulates macrophage activation, regulates the production of cytokines and enhances the severity of experimental autoimmune encephalomyelitis in mice [1] .

Hepatitis A virus cellular receptor 2 homolog; T cell immunoglobulin and mucin domain3; HAVCR2; CD366; TIM3

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Room temperature in continental US; may vary elsewhere.