protein

OSMR beta Protein, Human (HEK293, His)

HY-P72500

10 μg;50 μg

90;250 USD

OSMR beta Protein, Human (HEK293, His)

proteins

HEK293

10 μg;50 μg

90;250 USD

The OSMR beta protein is critical in immune responses by binding to IL12RB1 to form the interleukin 23 receptor with IL-23R. It binds to IL23 and activates T cells, NK cells and potentially macrophages/myeloid cells through Jak-Stat signaling. OSMR beta Protein, Human (712a.a, HEK293, His) is the recombinant human-derived OSMR beta protein, expressed by HEK293 , with C-6*His labeled tag. The total length of OSMR beta Protein, Human (712a.a, HEK293, His) is 712 a.a., with molecular weight of ~132 kDa.

Human

The IL-23R protein plays a critical role in immune response by forming the interleukin-23 receptor through its association with IL12RB1. This receptor binds to IL23 and triggers the activation of T-cells, NK cells, and potentially certain macrophage/myeloid cells via the Jak-Stat signaling cascade. IL23 is involved in both innate and adaptive immunity and likely contributes to the acute response to infection in peripheral tissues. Additionally, IL23 is implicated in autoimmune inflammatory diseases and has been shown to be important in tumorigenesis. When IL12RB1 is present, IL-23R forms a heterodimer that acts as the IL-23 receptor and interacts with JAK2 to activate STAT3.

Oncostatin-M-specific receptor subunit beta; IL-31R-beta; IL-31RB; OSMR; OSMRB

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized from a 0.2 μm filtered solution of 20 mM PB, 150 mM NaCl, pH 7.2.

Room temperature in continental US; may vary elsewhere.