protein

PD-L2 Protein, Rhesus macaque/Cynomolgus (HEK293, His)

HY-P72493

10 μg;50 μg

84;235 USD

PD-L2 Protein, Rhesus macaque/Cynomolgus (HEK293, His)

proteins

HEK293

10 μg;50 μg

84;235 USD

PDCD1LG2 is an immune checkpoint receptor ligand that binds to PD-1 to activate pathways that inhibit TCR/ BCR-mediated immune cell activation. PDCD1LG2 can inhibit T-cell proliferation and inflammatory cytokine production. The expression of PDCD1LG2 on mouse tumor cells inhibits cytotoxic T-cell-mediated immune responses and can be used as a biomarker or prognostic indicator. PD-L2 Protein, Rhesus macaque/Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived PD-L2 protein, expressed by HEK293 , with C-6*His labeled tag.

Rhesus Macaque;Cynomolgus

Programmed cell death 1 ligand 2 is a cell surface receptor also known as PD-L2, B7-DC or CD273. PDCD1LG2 is an immune checkpoint receptor ligand that plays a negative regulatory role in adaptive immune response. PDCD1LG2 binds to PD-1 to activate pathways that inhibit TCR/ BCR-mediated immune cell activation. PDCD1LG2 plays an important role in immune tolerance and autoimmunity, and both PD-L1 and PDCD1LG2 can inhibit T cell proliferation and inflammatory cytokine production. Blocking PDCD1LG2 exacerbates experimental autoimmune encephalomyelitis. PDCD1LG2 triggers IL-12 production in mouse dendritic cells, leading to T-cell activation. Treatment with PDCD1LG2 Ig led to a proliferation of T helper cells. The expression of PDCD1LG2 on mouse tumor cells inhibits cytotoxic T cell-mediated immune responses and can be used as a biomarker or prognostic indicator [1] [2] [3] [4] [5] .

Programmed cell death 1 ligand 2; Pdcd1lg2; PD-1 ligand 2; PD-L2; PDCD1 ligand 2; B7-DC; CD273

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Room temperature in continental US; may vary elsewhere.