protein

PD-L2 Protein, Human (HEK293, His)

HY-P72492

5 μg;10 μg;50 μg;100 μg

39;63;165;260 USD

PD-L2 Protein, Human (HEK293, His)

proteins

HEK293

5 μg;10 μg;50 μg;100 μg

39;63;165;260 USD

PD-L2 Protein, operating independently of PDCD1, plays a vital role in T-cell proliferation and IFNG production. Its interaction with PDCD1 inhibits proliferation and cytokine production. The interplay between PD-L2 and PDCD1 regulates immune responses, influencing T-cell activation and function. This molecular interaction adds complexity to mechanisms governing T-cell behavior, highlighting PD-L2's versatile role in immune regulation. PD-L2 Protein, Human (HEK293, His) is the recombinant human-derived PD-L2 protein, expressed by HEK293 , with C-His labeled tag.

Human

PD-L2 Protein is integral to the costimulatory signal crucial for T-cell proliferation and IFNG production, operating in a PDCD1-independent manner. Its interaction with PDCD1, however, functions to inhibit T-cell proliferation by impeding cell cycle progression and cytokine production. The intricate interplay between PD-L2 and PDCD1 underscores its role as a regulatory checkpoint in modulating immune responses, influencing the activation and function of T cells. This molecular interaction adds a layer of complexity to the dynamic mechanisms governing T-cell behavior, highlighting PD-L2's versatile role in immune regulation.

Programmed cell death 1 ligand 2; Pdcd1lg2; PD-1 ligand 2; PD-L2; PDCD1 ligand 2; B7-DC; CD273

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized from a 0.2 μm filtered solution of 20 mM PB,150 mM NaCl, pH 7.4 or PBS, pH 7.4, 5% Trehalose, 5% Mannitol.

Room temperature in continental US; may vary elsewhere.