protein

TGFBR1/ALK-5 Protein, Mouse (HEK293, Fc)

HY-P72454

10 μg;50 μg

166;465 USD

TGFBR1/ALK-5 Protein, Mouse (HEK293, Fc)

proteins

HEK293

10 μg;50 μg

166;465 USD

TGFBR1 is a transmembrane kinase that cooperates with TGFBR2 to form the TGF-β receptor complex.This complex is activated by cytokines and regulates a variety of processes, including cell cycle arrest, mesenchymal cell control, wound healing, and carcinogenesis.TGFBR1/ALK-5 Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived TGFBR1/ALK-5 protein, expressed by HEK293 , with C-hFc labeled tag.

Mouse

TGFBR1, a transmembrane serine/threonine kinase, forms a complex with the TGF-beta type II serine/threonine kinase receptor, TGFBR2, constituting the specific receptor for TGF-beta cytokines, including TGFB1, TGFB2, and TGFB3. This receptor complex plays a crucial role in transducing signals from the cell surface to the cytoplasm, thereby regulating a diverse range of physiological and pathological processes. These include inducing cell cycle arrest in epithelial and hematopoietic cells, controlling mesenchymal cell proliferation and differentiation, influencing wound healing, extracellular matrix production, immunosuppression, and participating in carcinogenesis. The assembly of the receptor complex, consisting of two TGFBR1 and two TGFBR2 molecules symmetrically bound to the cytokine dimer, leads to the constitutive activation of TGFBR1 by the catalytically active TGFBR2. Activated TGFBR1 phosphorylates SMAD2, causing its dissociation from the receptor and subsequent interaction with SMAD4. The resulting SMAD2-SMAD4 complex translocates to the nucleus, where it modulates the transcription of TGF-beta-regulated genes, initiating the canonical SMAD-dependent TGF-beta signaling cascade. Additionally, TGFBR1 is involved in non-canonical, SMAD-independent TGF-beta signaling pathways. For instance, it induces TRAF6 autoubiquitination, leading to MAP3K7 ubiquitination and activation, triggering apoptosis. Moreover, TGFBR1 regulates epithelial to mesenchymal transition through a SMAD-independent signaling pathway involving PARD6A phosphorylation and activation.

TGF-beta receptor type-1; ALK-5; SKR4; TbetaR-I; AAT5

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Room temperature in continental US; may vary elsewhere.