protein

BMP-15 Protein, Human (His, Myc)

HY-P72426

5 μg;10 μg;50 μg

75;125;350 USD

BMP-15 Protein, Human (His, Myc)

proteins

E. coli

5 μg;10 μg;50 μg

75;125;350 USD

Bone morphogenetic protein 15 (BMP-15; GDF9B), also known as growth differentiation factor 9B (GDF9B), is a polymorphic ligand protein of the TGFβ family and is only expressed in follicular cells. BMP15 is closely related to GDF9 and synergistically regulates the genetic development of follicles. BMP15 is involved in p38 MAPK and HIF-1α/SCF signaling pathway, respectively, and can up-regulate the expression of anti-Mullerian hormone (AMH) and polycystic ovarian syndrome (PCOS) related stem cell factor (SCF) in granulosa cells. The total length of human BMP-15 protein is 392 amino acids (M1-R392), with 4 glycosylation domains. BMP-15 Protein, Human (His, Myc) has a total length of 125 amino acids (Q268-R392), is expressed in E. coli cells with a N-terminal His-tag, a C-terminal Myc-tag, respectively.

Human

Bone morphogenetic protein 15 (BMP-15; GDF9B), also known as growth and differentiation factor 9B (GDF9B), is a polymorphic ligand protein belonging to the TGFβ family and expresses exclusively in the oocyte [1] . BMP15 is closely related to GDF9, which is essential for early ovarian folliculogenesis [1] . BMP15 and GDF9 involve in the genetic control of follicular development. Their main functions include regulating cellular proliferation/differentiation, follicular survival/atresia, and oocyte maturation, to creat an environment supporting follicle selection and growth [2] . BMP15 involves in p38 MAPK pathway to up-regulate anti-Mullerian hormone (AMH) expression in granulosa cells, which is produced by granulosa cells (GCs) of preantral and small antral follicles and plays a role in regulating the recruitment of primordial follicles and the FSH-dependent development of follicles [3] . Otherwise, BMP15 binds HIF-1α/SCF signaling pathway to induce stem cell factor (SCF) expression in human GCs of polycystic ovary syndrome (PCOS) related follicles [4] . BMP-15 is widely found in different animals, while the sequence in human is different from rat (63.66%), and mouse (64.01).

Growth/differentiation factor 9B

Greater than 90% as determined by reducing SDS-PAGE.

Lyophilized from a 0.2 μm filtered solution of Tris/PBS-based buffer, 6% Trehalose, pH 8.0.

Room temperature in continental US; may vary elsewhere.