protein

ROR1 Protein, Human (Biotinylated, HEK293, His-Avi)

HY-P72410

20 μg;100 μg

285;800 USD

ROR1 Protein, Human (Biotinylated, HEK293, His-Avi)

proteins

HEK293

20 μg;100 μg

285;800 USD

ROR1 protein's minimal kinase activity in vitro suggests an improbable role as a tyrosine kinase in vivo. It serves as a receptor for WNT5A, activating NFkB signaling and potentially inhibiting WNT3A signaling. Notably, ROR1 plays a vital role in the inner ear, facilitating innervation of auditory hair cells by spiral ganglion neurons. ROR1 Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived ROR1 protein, expressed by HEK293 , with C-Avi, C-6*His labeled tag. The total length of ROR1 Protein, Human (Biotinylated, HEK293, His-Avi) is 374 a.a., with molecular weight of 55-80 kDa.

Human

ROR1 protein exhibits very low kinase activity in vitro, suggesting an unlikely role as a tyrosine kinase in vivo. It functions as a receptor for the ligand WNT5A, activating downstream NFkB signaling pathways and potentially inhibiting WNT3A-mediated signaling. Notably, in the inner ear, ROR1 is crucial for facilitating the innervation of auditory hair cells by spiral ganglion neurons.

Inactive tyrosine-protein kinase transmembrane receptor ROR1; Neurotrophictyrosine kinase, receptor-related 1; NTRKR1

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Room temperature in continental US; may vary elsewhere.