protein

P-selectin Protein, Mouse (Biotinylated, HEK293, Avi-His)

HY-P72408

20 μg;100 μg

300;750 USD

P-selectin Protein, Mouse (Biotinylated, HEK293, Avi-His)

proteins

HEK293

20 μg;100 μg

300;750 USD

P-selectin is a Ca(2+)-dependent receptor on myeloid cells that specifically binds to carbohydrates on neutrophils and monocytes.It mediates interactions between activated endothelial cells or platelets and leukocytes by recognizing sialic acid-Lewis X.P-selectin Protein, Mouse (Biotinylated, HEK293, Avi-His) is the recombinant mouse-derived P-selectin protein, expressed by HEK293 , with C-Avi, C-6*His labeled tag.

Mouse

The P-selectin protein is a Ca(2+)-dependent receptor found on myeloid cells, which specifically binds to carbohydrates on neutrophils and monocytes. It plays a crucial role in mediating the interaction between activated endothelial cells or platelets and leukocytes. The ligand recognized by P-selectin is sialyl-Lewis X. P-selectin facilitates the rapid rolling of leukocytes over vascular surfaces during the initial stages of inflammation by interacting with SELPLG. It also interacts with SNX17. Moreover, P-selectin interacts with SELPLG/PSGL1 and PODXL2, promoting neutrophil adhesion and leukocyte rolling. This interaction requires the presence of the sialyl-Lewis X epitope on SELPLG and PODXL2, as well as specific tyrosine sulfation on SELPLG.

CD62 antigen-like family member P; GMP-140; LECAM3; PADGEM

Greater than 90% as determined by reducing SDS-PAGE.

Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.

Room temperature in continental US; may vary elsewhere.