protein

LAIR1 Protein, Human (Biotinylated, HEK293, Avi-His)

HY-P72390

20 μg;100 μg

300;850 USD

LAIR1 Protein, Human (Biotinylated, HEK293, Avi-His)

proteins

HEK293

20 μg;100 μg

300;850 USD

LAIR1 protein has a negative regulatory effect on NK cells, B cells and T cells. It activates the phosphatases PTPN6 and PTPN11, inhibits calcium increases in B cells, and regulates cytokine production in CD4+ T cells. LAIR1 Protein, Human (Biotinylated, HEK293, Avi-His) is the recombinant human-derived LAIR1 protein, expressed by HEK293 , with C-Avi, C-6*His labeled tag.

Human

The LAIR1 Protein serves as an inhibitory receptor, exerting a constitutive negative regulatory influence on the cytolytic function of natural killer (NK) cells, B-cells, and T-cells. Upon activation through tyrosine phosphorylation, it recruits and activates phosphatases PTPN6 and PTPN11. LAIR1 also dampens the increase in intracellular calcium triggered by B-cell receptor ligation. Beyond its dependency on SH2-containing phosphatases, it independently modulates cytokine production in CD4+ T-cells, suppressing IL2 and IFNG while promoting the secretion of transforming growth factor beta. Additionally, LAIR1 down-regulates IgG and IgE production in B-cells and hinders the secretion of IL8, IL10, and TNF. In myeloid leukemia cell lines, LAIR1 inhibits proliferation, induces apoptosis, and prevents nuclear translocation of NF-kappa-B p65 subunit/RELA, along with the phosphorylation of I-kappa-B alpha/CHUK. Moreover, LAIR1 inhibits the differentiation of peripheral blood precursors into dendritic cells. It interacts with the SH2 domains of tyrosine-protein phosphatases PTPN6 and PTPN11, with the interaction with PTPN6 being constitutive. Furthermore, LAIR1 binds with high affinity to extracellular matrix collagens, highlighting the functional importance of this interaction.

Leukocyte-Associated Immunoglobulin-Like Receptor 1; LAIR-1; hLAIR1; CD305; LAIR1

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized from a 0.2 μm filtered solution of 20 mM PB, 150 mM NaCl, pH 7.2.

Room temperature in continental US; may vary elsewhere.