protein

FCRN-B2M Protein, Human (Biotinylated, HEK293, His-Avi)

HY-P72368

20 μg;100 μg

420;1180 USD

FCRN-B2M Protein, Human (Biotinylated, HEK293, His-Avi)

proteins

HEK293

20 μg;100 μg

420;1180 USD

FCGRT is an IgG Fc receptor. Fc receptor expression is up-regulated by pro-inflammatory cytokines TNF and down-regulated by IFN-γ . FCGRT plays a role in regulating IgG and serum albumin conversion. Overexpression of FCGRT is also associated with poor prognosis of tumors. FCRN-B2M Protein, Human (Biotinylated, HEK293, His-Avi) is a recombinant protein dimer complex containing human-derived FCRN-B2M protein, expressed by HEK293 , with C-Avi, C-6*His labeled tag. FCRN-B2M Protein, Human (Biotinylated, HEK293, His-Avi), has molecular weight of 35 & 13 kDa, respectively.

Human

IgG receptor FcRn large subunit p51 is an IgG Fc receptor with a molecular structure similar to MHC Class I and also binds to β-2 microglobulin. In rodents, FcRn was originally thought to be a receptor that trantranks maternal immunoglobulin G (IgG) from mother to newborn offspring via breast milk and is therefore known as a neonatal Fc receptor. FcRn has also been shown to play a role in regulating IgG and serum albumin conversion, and neonatal Fc receptor expression is up-regulated by pro-inflammatory cytokines TNF and down-regulated by IFN-γ . In the acidic endosomes of endothelial and hematopoietic cells, monomer IgG binds to FcRn, circulates IgG to the cell surface, where it is released into the circulation, regulating, in addition to IgG, homeostasis of the circulating protein albumin /ALB. The up-regulated expression of FCGRT in bladder cancer may serve as a key neutrophil gene associated with poor prognosis. FCGRT overexpression was also associated with decreased PD-L1 expression and decreased tumor mutation load (TMB) level [1] [2] [3] [4] [5] [6] .

IgG receptor FcRn; Neonatal Fc receptor; FCRN

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized from a 0.2 μm filtered solution of 20mM PB, 6% Sucrose, 4% Mannitol, 0.05% Tween 80, pH 7.8

Room temperature in continental US; may vary elsewhere.