protein

EpCAM/TROP1 Protein, Human (Biotinylated, HEK293, His-Avi)

HY-P72367

20 μg;100 μg

268;750 USD

EpCAM/TROP1 Protein, Human (Biotinylated, HEK293, His-Avi)

proteins

HEK293

20 μg;100 μg

268;750 USD

The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived EpCAM/TROP1 protein, expressed by HEK293 , with C-Avi, C-6*His labeled tag. The total length of EpCAM/TROP1 Protein, Human (Biotinylated, HEK293, His-Avi) is 242 a.a., with molecular weight of 35-50 kDa.

Human

The EpCAM/TROP1 Protein emerges as a pivotal entity, potentially functioning as a physical homophilic interaction molecule that fosters direct contact between intestinal epithelial cells (IECs) and intraepithelial lymphocytes (IELs) at the mucosal epithelium, thereby contributing to the establishment of an immunological barrier as the primary defense against mucosal infections. Beyond its role in mucosal immunity, this protein plays a significant part in the proliferation and differentiation of embryonic stem cells. It further exhibits regulatory influence by up-regulating the expression of FABP5, MYC, and cyclins A and E, implicating EpCAM/TROP1 in the modulation of key cellular processes. Its monomeric nature and interaction with phosphorylated CLDN7 underscore the intricate molecular interactions involved, providing insights into the diverse functions of this protein in cellular physiology.

Epithelial Cell Adhesion Molecule; Cell Surface Glycoprotein Trop-1; EGP; EGP314; hEGP314; KSA; CD326

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized from a 0.2 μm filtered solution of 20 mM PB, 150 mM NaCl, pH 7.2.

Room temperature in continental US; may vary elsewhere.