protein

Leptin Protein, Rat

HY-P7233

2 μg;10 μg;50 μg;100 μg;200 μg

30;42;58;82;115 USD

Leptin Protein, Rat

proteins

E. coli

2 μg;10 μg;50 μg;100 μg;200 μg

30;42;58;82;115 USD

377622367

Leptin Protein, Rat is a hormone secreted by fat cells that helps to regulate energy balance by inhibiting feeding and increase thermogenesis.

Rat

A sensor (leptin production by adipose cells) monitors the size of the adipose tissue mass. Hypothalamic centers receive and integrate the intensity of the leptin signal through leptin receptors (LRb). Effector systems, including the sympathetic nervous system, control the two main determinants of energy balance-energy intake and energy expenditure [1] . Recessive mutations in the leptingene are associated with massive obesity in mice and humans, establishing a genetic basis for obesity. Leptin circulates in blood and acts on the brain to regulate food intake and energy expenditure. When fat mass falls, plasma leptin levels fall, stimulating appetite and suppressing energy expenditure until fat mass is restored. When fat mass increases, leptin levels increase, suppressing appetite until weight is lost. This system maintains homeostatic control of adipose tissue mass [2] .

rRtLeptin; Obesity protein (OB)

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized after extensive dialysis against 50 mM Tris, pH 8.0 or 50 mM Tris-HCL, 200 mM NaCl, pH 8.0, 5% trehalose, 5% mannitol and 0.01% Tween80.

Room temperature in continental US; may vary elsewhere.