protein

Intermediate capsid protein VP6, Rotavirus A (sf9, His)

HY-P72302A

50 μg

365 USD

Intermediate capsid protein VP6, Rotavirus A (sf9, His)

proteins

Sf9 insect cells

50 μg

365 USD

The intermediate capsid protein VP6 self-assembles into an icosahedral capsid with T=13 symmetry, forming the middle layer of the virus particle. It contains 230 VP6 trimers that protect dsRNA and prevent host cell antiviral responses. Intermediate capsid protein VP6, Rotavirus A (sf9, His) is the recombinant Virus-derived Intermediate capsid protein VP6, expressed by Sf9 insect cells , with N-His, C-Myc labeled tag. The total length of Intermediate capsid protein VP6, Rotavirus A (sf9, His) is 397 a.a., with molecular weight of ~45 kDa.

Virus

The intermediate capsid protein VP6 functions as a self-assembling component, forming an icosahedral capsid with T=13 symmetry. This capsid, comprising 230 VP6 trimers, constitutes the middle concentric layer of the viral mature particle. During the virus replication cycle, VP6, along with the innermost VP2 capsid, remains intact following cell entry, providing protection to the dsRNA from degradation and preventing unfavorable antiviral responses in the host cell. The VP6 capsid plays a crucial role in the transcription activity of the double-layered particle (DLP), where nascent transcripts are transcribed within its structural confines and extruded through the channels at the five-fold axes. VP6 interacts with the inner capsid protein VP2, the outer capsid glycoprotein VP7, and the outer capsid protein VP5*, forming essential interactions for the overall functionality of the viral capsid.

Intermediate capsid protein VP6

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized from a 0.22 μm filtered solution of 20 mM Tris-HCL, 500 mM NaCl, pH 8.0, 10% Glycerol.

Room temperature in continental US; may vary elsewhere.