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company name :
MedChem Express LLC
product type :
protein
product name :
Group XV phospholipase A2/Pla2g15, Mouse (His, myc)
catalog :
HY-P72293
quantity :
2 μg;10 μg;50 μg
price :
58;145;305 USD
more info or order :
product information
Catalog Number :
HY-P72293
Product Name :
Group XV phospholipase A2/Pla2g15, Mouse (His, myc)
Product Type :
proteins
Host Species :
E. coli
Size :
2 μg;10 μg;50 μg
List Price :
58;145;305 USD
Product Description :
Group XV phospholipase A2 (Pla2g15) exhibits dual calcium-dependent phospholipase and O-acyltransferase activities that contribute to glycerophospholipid homeostasis and acyl remodeling in acidic cellular compartments. Group XV phospholipase A2/Pla2g15, Mouse (His, myc) is the recombinant mouse-derived Group XV phospholipase A2/Pla2g15, expressed by E. coli , with N-His, C-Myc labeled tag. The total length of Group XV phospholipase A2/Pla2g15, Mouse (His, myc) is 379 a.a., with molecular weight of ~50.5 kDa.
SpeciesSummary :
Mouse
Background :
Group XV phospholipase A2 (Pla2g15) exhibits dual calcium-independent phospholipase and O-acyltransferase activities, potentially contributing to glycerophospholipid homeostasis and the remodeling of acyl groups in acidic cellular compartments. The enzyme catalyzes the hydrolysis of the ester bond of the fatty acyl group at sn-1 or sn-2 positions of phospholipids, demonstrating both phospholipase A1 and A2 activities, and transfers it to the hydroxyl group at the first carbon of lipophilic alcohols through O-acyltransferase activity. Pla2g15 prefers fatty acyl donors such as phosphatidylcholines, phosphatidylethanolamines, phosphatidylglycerols, and phosphatidylserines, favoring sn-2 over sn-1 deacylation of unsaturated fatty acyl groups. Additionally, it selectively hydrolyzes the sn-1 fatty acyl group of truncated oxidized phospholipids, potentially participating in the detoxification of reactive oxidized phospholipids during oxidative stress. Pla2g15 plays a vital role in phospholipid degradation in alveolar macrophages, suggesting implications in pulmonary surfactant clearance. At neutral pH, it hydrolyzes the sn-1 fatty acyl group of lysophosphatidylcholines.
ALTnames :
Group XV phospholipase A2; 1-O-acylceramide synthase; ACS; LLPL; Lysosomal phospholipase A2
Purity :
Greater than 90% as determined by reducing SDS-PAGE.
Buffer :
Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4.
Storage :
Room temperature in continental US; may vary elsewhere.
more info or order :
company information
MedChem Express LLC
18 Wilkinson Way, Princeton, NJ 08540
sales@medchemexpress.com
http://www.medchemexpress.com609-228-6898
headquarters: USA