protein

Vitamin D-binding protein/GC Protein, Mouse (His)

HY-P72292

2 μg;10 μg;50 μg

58;145;305 USD

Vitamin D-binding protein/GC Protein, Mouse (His)

proteins

E. coli

2 μg;10 μg;50 μg

58;145;305 USD

Vitamin D-binding proteins (GC proteins) play key roles in vitamin D transport and storage and in the clearance of extracellular G-actin. It enhances the C5 alpha chemotactic activity of neutrophils, participates in macrophage activation, and binds to membrane-bound immunoglobulins on B lymphocytes. Vitamin D-binding protein/GC Protein, Mouse (His) is the recombinant mouse-derived Vitamin D-binding protein/GC protein, expressed by E. coli , with N-His labeled tag. The total length of Vitamin D-binding protein/GC Protein, Mouse (His) is 460 a.a., with molecular weight of ~57.4 kDa.

Mouse

Vitamin D-binding protein (GC Protein) plays a pivotal role in vitamin D transport and storage, contributing to the scavenging of extracellular G-actin. Additionally, it enhances the chemotactic activity of C5 alpha for neutrophils during inflammation and participates in macrophage activation. Notably, GC Protein associates with membrane-bound immunoglobulin on the surface of B-lymphocytes and interacts with IgG Fc receptor on the membranes of T-lymphocytes, suggesting its involvement in immune-related processes. Furthermore, its interaction with LRP2 is crucial for the renal uptake of GC in complex with 25-hydroxyvitamin D3, highlighting its significance in vitamin D metabolism.

Vitamin D-binding protein; DBP; VDB; Gc-globulin; Group-specific component

Greater than 90% as determined by reducing SDS-PAGE.

Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4.

Room temperature in continental US; may vary elsewhere.