protein

Cardiac phospholamban/PLN, Human (P.pastoris, GST)

HY-P72275

2 μg;10 μg;50 μg

51;128;355 USD

Cardiac phospholamban/PLN, Human (P.pastoris, GST)

proteins

P. pastoris

2 μg;10 μg;50 μg

51;128;355 USD

Cardiac phospholamban (PLN) strictly regulates ATP2A2 in the cardiac sarcoplasmic reticulum, reversibly inhibits ATPase activity and affects myocardial contractility. Modulation of PLN reduces the affinity of ATPase for Ca(2+), thereby affecting calcium reuptake during muscle relaxation and maintaining cardiac calcium homeostasis. Cardiac phospholamban/PLN, Human (P.pastoris, GST) is the recombinant human-derived Cardiac phospholamban/PLN, expressed by P. pastoris , with N-GST labeled tag. The total length of Cardiac phospholamban/PLN, Human (P.pastoris, GST) is 52 a.a., with molecular weight of ~33.1 kDa.

Human

Cardiac phospholamban (PLN) is a key regulator that reversibly inhibits the activity of ATP2A2 in the cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). This modulation of ATP2A2 by PLN significantly influences the contractility of the heart muscle in response to physiological stimuli, impacting calcium re-uptake during muscle relaxation and playing a crucial role in maintaining calcium homeostasis within the heart muscle. The extent of ATP2A2 inhibition is contingent on the oligomeric state of PLN, and phosphorylation of PLN alleviates ATP2A2 inhibition. PLN also exerts control over intracellular Ca(2+) levels in elongated spermatids, suggesting a potential role in germ cell differentiation. As a homopentamer, PLN interacts with various proteins, including HAX1, ATP2A2, VMP1, and S100A1, contributing to its multifaceted regulatory functions in cellular processes.

Cardiac phospholamban; CMD1P; CMH18

Greater than 90% as determined by reducing SDS-PAGE.

Lyophilized from a 0.2 μm sterile filtered 20 mM Tris-HCl, 0.5 M NaCl, 3% Trehalose, pH 8.0.

Room temperature in continental US; may vary elsewhere.