protein

TPM2 Protein, Human (His)

HY-P72264

2 μg;10 μg;50 μg

41;100;282 USD

TPM2 Protein, Human (His)

proteins

E. coli

2 μg;10 μg;50 μg

41;100;282 USD

The TPM2 protein binds actin filaments in muscle and nonmuscle cells and centrally regulates calcium-dependent striated muscle contraction in vertebrates, particularly in concert with the troponin complex. In smooth muscle cells, TPM2 helps regulate contraction by interacting with calcium-binding proteins. TPM2 Protein, Human (His) is the recombinant human-derived TPM2 protein, expressed by E. coli , with N-6*His labeled tag. The total length of TPM2 Protein, Human (His) is 271 a.a., with molecular weight of ~38 kDa.

Human

TPM2 protein exhibits specific binding to actin filaments in both muscle and non-muscle cells, playing a central role in the calcium-dependent regulation of vertebrate striated muscle contraction, particularly in association with the troponin complex. In smooth muscle cells, TPM2 contributes to the regulation of contraction through its interaction with caldesmon. Moreover, in non-muscle cells, TPM2 is implicated in the stabilization of actin filaments within the cytoskeleton, indicating its versatile functions across cellular contexts. The non-muscle isoform of TPM2 may additionally participate in agonist-mediated receptor internalization. Structurally, TPM2 forms homodimers and heterodimers, the latter composed of an alpha chain (TPM1, TPM3, or TPM4) and a beta chain (TPM2), highlighting its diverse molecular associations and underscoring its pivotal roles in both muscle contraction and cellular structural dynamics.

AMCD1; TMSA; TMSB; TPM2; TRK; Tropomyosin beta chain

Greater than 90% as determined by reducing SDS-PAGE.

Lyophilized from a 0.2 μm sterile filtered PBS , 6% Trehalose, pH 7.4.

Room temperature in continental US; may vary elsewhere.