protein

HAS2 Protein, Mouse (His)

HY-P72222

20 μg;50 μg

135;300 USD

HAS2 Protein, Mouse (His)

proteins

E. coli

20 μg;50 μg

135;300 USD

The HAS2 protein adds GlcNAc or GlcUA monosaccharides to hyaluronic acid, playing a crucial role in its synthesis. HAS2 Protein, Mouse (His) is the recombinant mouse-derived HAS2 protein, expressed by E. coli , with N-6*His labeled tag. The total length of HAS2 Protein, Mouse (His) is 308 a.a., with molecular weight of ~39.9 kDa.

Mouse

HAS2 protein plays a pivotal role in hyaluronan synthesis by catalyzing the addition of GlcNAc or GlcUA monosaccharides to the nascent hyaluronan polymer. As a key isozyme involved in this process, HAS2 contributes significantly to the formation of high molecular mass hyaluronan, a major component of most extracellular matrices. This hyaluronan polymer, with its structural role in tissue architectures, plays a crucial role in regulating cell adhesion, migration, and differentiation. HAS2's importance extends to developmental processes, as it is required for the transition of endocardial cushion cells into mesenchymal cells, a critical step in heart development. Additionally, HAS2 may play a role in vasculogenesis. The synthesis of high molecular mass hyaluronan by HAS2 is particularly noteworthy in early contact inhibition, a cellular process that halts growth upon cell contact with other cells or the extracellular matrix. In summary, HAS2 emerges as a central player in the intricate orchestration of hyaluronan-mediated cellular and developmental functions.

Has2; Hyaluronan synthase 2; EC 2.4.1.212; Hyaluronate synthase 2; Hyaluronic acid synthase 2; HA synthase 2

Greater than 90% as determined by reducing SDS-PAGE.

Lyophilized from a 0.2 μm solution of 10 mM Tris-HCl, 1 mM EDTA, 6% Trehalose, pH 8.0 or 50 mM Tris-HCL, 200 mM NaCl, pH 8.0, 1 mM EDTA, 8% trehalose.

Room temperature in continental US; may vary elsewhere.