protein

EPHX1 Protein, Human (His-SUMO)

HY-P72184

20 μg;50 μg

125;238 USD

EPHX1 Protein, Human (His-SUMO)

proteins

E. coli

20 μg;50 μg

125;238 USD

The EPHX1 protein is an important biotransformation enzyme that hydrolyzes aromatic hydrocarbons and aliphatic epoxides by catalyzing the transaddition of water. This makes the epoxide less reactive and more water-soluble. EPHX1 Protein, Human (His-SUMO) is the recombinant human-derived EPHX1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag. The total length of EPHX1 Protein, Human (His-SUMO) is 455 a.a., with molecular weight of ~66 kDa.

Human

The EPHX1 protein serves as a crucial biotransformation enzyme, facilitating the hydrolysis of both arene and aliphatic epoxides. Through the trans addition of water, EPHX1 catalyzes this transformation, rendering the epoxides less reactive and more water-soluble. Beyond its role in xenobiotic metabolism, EPHX1 plays a significant role in the metabolic pathways of endogenous lipids, particularly in the processing of epoxide-containing fatty acids. Notably, EPHX1 participates in the metabolism of the abundant endocannabinoid 2-arachidonoylglycerol (2-AG), converting it into free arachidonic acid (AA) and glycerol. These enzymatic activities highlight the versatile role of EPHX1 in modulating the bioavailability and reactivity of various substrates, contributing to essential cellular processes and lipid metabolism.

EPHX 1; EPHX; Ephx1; EPOX; Epoxide hydratase; Epoxide hydrolase 1; Epoxide hydrolase 1 microsomal xenobiotic; ; Epoxide hydroxylase 1; Epoxide hydroxylase 1 microsomal xenobiotic; ; HYEP_HUMAN; HYL1; MEH; Microsomal epoxide hydrolase

Greater than 90% as determined by reducing SDS-PAGE.

Lyophilized from a 0.2 μm solution of 10 mM Tris-HCl, 1 mM EDTA, 6% Trehalose, pH 8.0.

Room temperature in continental US; may vary elsewhere.