protein

ELANE Protein, Human (GST)

HY-P72179

5 μg;10 μg;20 μg;50 μg

123;209;320;585 USD

ELANE Protein, Human (GST)

proteins

E. coli

5 μg;10 μg;20 μg;50 μg

123;209;320;585 USD

ELANE is a serine protease that critically regulates natural killer cells, monocytes, and granulocytes by inhibiting C5a-dependent neutrophil enzyme release and chemotaxis, thereby shaping immune responses. It also inhibits pyroptosis by cleaving GSDMB, affecting the regulation of programmed cell death. ELANE Protein, Human (GST) is the recombinant human-derived ELANE protein, expressed by E. coli , with N-GST labeled tag. The total length of ELANE Protein, Human (GST) is 238 a.a., with molecular weight of ~52.6 kDa.

Human

ELANE, a serine protease, plays a crucial role in modulating the functions of natural killer cells, monocytes, and granulocytes. It acts by inhibiting C5a-dependent neutrophil enzyme release and chemotaxis, highlighting its regulatory role in immune responses. Additionally, ELANE participates in the inhibition of pyroptosis by promoting the cleavage of GSDMB, showcasing its involvement in the regulation of programmed cell death. Notably, ELANE exhibits bactericidal activity by effectively killing E. coli in vitro, while sparing S. aureus. This antimicrobial effect is attributed to its ability to digest outer membrane protein A (ompA) in E. coli and K. pneumoniae, underscoring its role in bacterial defense mechanisms.

Bone marrow serine protease; ELA2; ELANE; Elastase 2; Elastase 2 neutrophil; Elastase neutrophil expressed; Elastase-2; ELNE_HUMAN; GE; Granulocyte derived elastase; HLE; HNE; Human leukocyte elastase; Leukocyte elastase; Medullasin; NE; Neutrophil elastase; PMN E; PMN elastase; Polymorphonuclear elastase; SCN1

Greater than 90% as determined by reducing SDS-PAGE.

Lyophilized from a 0.2 μm solution of 10 mM Tris-HCl, 1 mM EDTA, 6% Trehalose, pH 8.0.

Room temperature in continental US; may vary elsewhere.