protein

DSP Protein, Human (His-SUMO)

HY-P72176

5 μg;10 μg;50 μg

85;145;400 USD

DSP Protein, Human (His-SUMO)

proteins

E. coli

5 μg;10 μg;50 μg

85;145;400 USD

DSP proteins are major components of desmosomes and are critical for the structural integrity of various tissues. In cardiomyocytes, DSP regulates profibrotic gene expression through MAPK14/p38 MAPK activation and increased TGFB1 protein. DSP Protein, Human (His-SUMO) is the recombinant human-derived DSP protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag. The total length of DSP Protein, Human (His-SUMO) is 223 a.a., with molecular weight of ~42.1 kDa.

Human

DSP Protein takes center stage as a major high molecular weight component of desmosomes, crucial for maintaining structural integrity in various tissues. In cardiomyocytes, DSP plays a regulatory role in profibrotic gene expression through the activation of the MAPK14/p38 MAPK signaling cascade and an increase in TGFB1 protein abundance, as evidenced by similarity-based observations. Existing as a homodimer, DSP engages in dynamic interactions with key desmosomal components, such as COL17A1, DSC2, PKP2, and PKP1, showcasing its integral role in the complex architecture of desmosomal junctions. Furthermore, DSP demonstrates a weak interaction with TMEM65, highlighting its potential involvement in diverse cellular processes beyond desmosome assembly. The multifaceted functions of DSP underscore its significance in cellular structure and signaling pathways.

250/210 kDa paraneoplastic pemphigus antigen; DCWHKTA; Desmoplakin DPI DPII; ; Desmoplakin; Desmoplakin I ; Desmoplakin II; DESP_HUMAN; DP; DP I; DP II; DPI; DPII; DSP; KPPS2; PPKS 2; PPKS2

Greater than 90% as determined by reducing SDS-PAGE.

Lyophilized from a 0.2 μm solution of 10 mM Tris-HCl, 1 mM EDTA, 6% Trehalose, pH 8.0.

Room temperature in continental US; may vary elsewhere.