protein

CYP11B2 Protein, Human (His-SUMO)

HY-P72163

5 μg;10 μg;50 μg

88;150;420 USD

CYP11B2 Protein, Human (His-SUMO)

proteins

E. coli

5 μg;10 μg;50 μg

88;150;420 USD

CYP11B2 Protein, a cytochrome P450 monooxygenase, synthesizes aldosterone, pivotal for salt and water balance, impacting blood pressure and cardiovascular health. Mechanistically, it orchestrates three oxidative reactions, forming aldosterone, utilizing molecular oxygen and a mitochondrial transfer system. Additionally, CYP11B2 may be involved in the androgen metabolic pathway, expanding its physiological roles. CYP11B2 Protein, Human (His-SUMO) is the recombinant human-derived CYP11B2 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag. The total length of CYP11B2 Protein, Human (His-SUMO) is 479 a.a., with molecular weight (affected by relative charge) of 66 KDa.

Human

The CYP11B2 protein, a cytochrome P450 monooxygenase, plays a crucial role in catalyzing the biosynthesis of aldosterone, the primary mineralocorticoid responsible for maintaining salt and water homeostasis in the human body. Its involvement in blood pressure regulation, arterial hypertension, and heart failure underscores its significance in cardiovascular health. Mechanistically, CYP11B2 orchestrates three sequential oxidative reactions of 11-deoxycorticosterone, involving 11-beta hydroxylation and two successive oxidations at C18, ultimately resulting in the formation of aldosterone. The enzyme utilizes molecular oxygen to insert one oxygen atom into the substrate, with the second oxygen atom reduced into a water molecule. This process is facilitated by a two-protein mitochondrial transfer system comprising flavoprotein FDXR (adrenodoxin/ferredoxin reductase) and nonheme iron-sulfur proteins FDX1 or FDX2 (adrenodoxin/ferredoxin), with two electrons supplied by NADPH. Additionally, CYP11B2 may be implicated in the androgen metabolic pathway, offering further insights into its diverse physiological roles.

ALDOS; Aldosterone synthase; Aldosterone-synthesizing enzyme; C11B2_HUMAN; CYP11B2; CYPXIB2; Cytochrome P-450Aldo; Cytochrome P-450C18; Cytochrome P450 11B2; Cytochrome P450 11B2; mitochondrial; mitochondrial; P-450Aldo; P-450C18; Steroid 18-hydroxylase

Greater than 90% as determined by reducing SDS-PAGE.

Lyophilized from a 0.2 μm sterile filtered PBS, 6% Trehalose, pH 7.4

Room temperature in continental US;may vary elsewhere.