protein

COL4A2 Protein, Human (His)

HY-P72147

5 μg;10 μg;50 μg

120;205;460 USD

COL4A2 Protein, Human (His)

proteins

E. coli

5 μg;10 μg;50 μg

120;205;460 USD

COL4A2 protein is a key type IV collagen element that forms the main structural component of the glomerular basement membrane (GBM), forming a unique "chicken wire" network structure with laminin, proteoglycans and nestin/nesidin. Canstatin is a cleavage product of the NC1 domain of collagen α 2(IV) and has potent anti-angiogenic and anti-tumor activities. COL4A2 Protein, Human (His) is the recombinant human-derived COL4A2 protein, expressed by E. coli , with N-6*His labeled tag. The total length of COL4A2 Protein, Human (His) is 220 a.a., with molecular weight of ~28.3 kDa.

Human

COL4A2 protein, a fundamental element of Type IV collagen, plays a central role as the major structural component in glomerular basement membranes (GBM), forming a characteristic 'chicken-wire' meshwork in conjunction with laminins, proteoglycans, and entactin/nidogen. Within this context, Canstatin, a cleavage product derived from the collagen alpha 2(IV) NC1 domain, exhibits notable anti-angiogenic and anti-tumor cell activities. Canstatin interferes with the proliferation and migration of endothelial cells, diminishes mitochondrial membrane potential, and induces apoptosis. Its mechanism includes the specific induction of Fas-dependent apoptosis, along with the activation of procaspase-8 and -9 activities. Notably, Canstatin acts as a ligand for alphavbeta3 and alphavbeta5 integrins, underscoring its multifaceted role in modulating cellular responses within the intricate context of Type IV collagen-rich environments like GBMs.

Canstatin; CO4A2_HUMAN; COL4A 2; Col4a2; Collagen alpha 2IV; chain; Collagen; type IV; alpha 2

Greater than 90% as determined by reducing SDS-PAGE.

Lyophilized from a 0.2 μm solution of 10 mM Tris-HCl, 1 mM EDTA, 6% Trehalose, pH 8.0.

Room temperature in continental US;may vary elsewhere.