protein

CHRNA1 Protein, Mouse (His)

HY-P72141

5 μg;10 μg

118;200 USD

CHRNA1 Protein, Mouse (His)

proteins

E. coli

5 μg;10 μg

118;200 USD

The CHRNA1 protein, also known as the acetylcholine receptor (AChR), undergoes significant conformational changes upon binding of acetylcholine. This change affects all subunits, causing the opening of ion-conducting channels across the plasma membrane. CHRNA1 Protein, Mouse (His) is the recombinant mouse-derived CHRNA1 protein, expressed by E. coli , with N-6*His labeled tag. The total length of CHRNA1 Protein, Mouse (His) is 210 a.a., with molecular weight of ~25 kDa.

Mouse

The CHRNA1 protein, also known as the alpha-1 subunit of the acetylcholine receptor (AChR), plays a crucial role in mediating cellular responses upon acetylcholine binding. As a component of the AChR, it is part of a pentameric structure consisting of two alpha chains, a beta, a delta, and either a gamma (in immature muscle) or epsilon (in mature muscle) chain. Upon acetylcholine binding, the AChR undergoes an extensive conformational change across all subunits, resulting in the opening of an ion-conducting channel across the plasma membrane. This process is integral to the transmission of nerve signals at the neuromuscular junction. Additionally, the muscle heteropentamer, comprising alpha-1, beta-1, delta, and epsilon subunits, interacts with the alpha-conotoxin ImII, further highlighting the intricate molecular interactions involved in the functionality of CHRNA1 within the acetylcholine receptor complex.

Chrna1; Acra; Acetylcholine receptor subunit alpha

Greater than 90% as determined by reducing SDS-PAGE.

Lyophilized from a 0.2 μm solution of 50 mM Tris-HCL, 300 mM NaCL, 200 mM arginine, pH 8.0.

Room temperature in continental US; may vary elsewhere.