protein

Complement Factor B/CFB Protein, Mouse (His)

HY-P72137

20 μg;50 μg

250;550 USD

Complement Factor B/CFB Protein, Mouse (His)

proteins

E. coli

20 μg;50 μg

250;550 USD

CFB is an important component of the alternative pathway of the complement system and is cleaved by factor D, producing two fragments: Ba and Bb. The Bb fragment is characterized as a serine protease and subsequently forms a complex with complement factor 3b, ultimately producing a C3 or C5 convertase. Complement Factor B/CFB Protein, Mouse (His) is the recombinant mouse-derived CFB protein, expressed by E. coli , with N-6*His labeled tag. The total length of Complement Factor B/CFB Protein, Mouse (His) is 739 a.a., with molecular weight of ~87 kDa.

Mouse

CFB, or complement factor B, is an integral component of the alternate pathway within the complement system. The protein undergoes cleavage by factor D, resulting in the formation of two distinct fragments: Ba and Bb. Of particular significance, Bb functions as a serine protease and subsequently associates with complement factor 3b. This complex formation gives rise to the C3 or C5 convertase, a pivotal enzyme involved in the activation of the complement cascade. The described molecular events underscore the central role of CFB in the intricate regulatory mechanisms of the complement system, shedding light on its contribution to immune responses.

Cfb; Bf; H2-BfComplement factor B; EC 3.4.21.47; C3/C5 convertase; Complement factor B Ba fragment; Complement factor B Bb fragment

Greater than 90% as determined by reducing SDS-PAGE.

Lyophilized from a 0.2 μm solution of 10 mM Tris-HCl, 1 mM EDTA, 6% Trehalose, pH 8.0.

Room temperature in continental US; may vary elsewhere.