protein

CAPZA2 Protein, Human (His-SUMO)

HY-P72116

20 μg;50 μg

158;300 USD

CAPZA2 Protein, Human (His-SUMO)

proteins

E. coli

20 μg;50 μg

158;300 USD

The CAPZA2 protein is a member of the F-actin capping protein family and binds to the barbed ends of actin filaments, preventing subunit exchange without severing the filaments. CAPZA2 Protein, Human (His-SUMO) is the recombinant human-derived CAPZA2 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag. The total length of CAPZA2 Protein, Human (His-SUMO) is 285 a.a., with molecular weight of ~48.8 kDa.

Human

The CAPZA2 protein, a member of F-actin-capping proteins, binds to the fast-growing ends of actin filaments (barbed end) in a Ca(2+)-independent manner, effectively blocking the exchange of subunits at these ends without severing actin filaments, distinguishing it from other capping proteins like gelsolin and severin. CAPZA2 functions as a heterodimer with an alpha and a beta subunit and is an integral component of the WASH complex, which comprises F-actin-capping protein subunit alpha (CAPZA1, CAPZA2, or CAPZA3), F-actin-capping protein subunit beta (CAPZB), and various WASH complex subunits. Additionally, CAPZA2 interacts with RCSD1/CAPZIP and directly associates with CRACD, with this interaction shown to decrease its binding to actin. The versatile nature of CAPZA2 in modulating actin dynamics highlights its role in regulating cytoskeletal architecture and cellular processes associated with actin filament organization.

CAPPA2 ; Capping protein actin filament; muscle Z line; alpha 2 ; CapZ alpha 2; CapZ alpha-2; CAPZ; CAPZA2; CAZA2_HUMAN; F actin capping protein alpha 2 subunit; F actin capping protein subunit alpha 2; F-actin-capping protein subunit alpha-2

Greater than 90% as determined by reducing SDS-PAGE.

Lyophilized from a 0.2 μm solution of 10 mM Tris-HCl, 1 mM EDTA, 6% Trehalose, pH 8.0.

Room temperature in continental US; may vary elsewhere.