IL-18BP Protein, Human (CHO) | MedChem Express LLC HY-P7211 product information

product summary

company name :

MedChem Express LLC

product type :

protein

product name :

IL-18BP Protein, Human (CHO)

catalog :

HY-P7211

quantity :

10 μg;50 μg

price :

90;190 USD

more info or order :

MedChem Express LLC product webpage

product information

Catalog Number :

HY-P7211

Product Name :

IL-18BP Protein, Human (CHO)

Product Type :

proteins

Host Species :

CHO

Size :

10 μg;50 μg

List Price :

90;190 USD

list of Pubmed id :

377622345

Product Description :

IL-18BP Protein, Human (CHO) Binding Protein (CHO-expressed) is a modulator of the Th1 cytokine response.

SpeciesSummary :

Human

Background :

IL18BP (Interleukin-18 Binding Protein) is an early signal in the development of T-lympho-cyte helper type 1 (Th1) responses [1] . IL18BP shares many characteristics with soluble cytokine receptors of the IL1 family in that the protein exhibits specificity for IL18, belongs to the immunoglobulin-like class of receptors and has limited amino acid sequences with those of the IL1 receptor type II. IL18BP suppresses the production of IFNγ resulting in reduced T-helper type 1 immune responses. Two human IL18BP isoforms exhibit the greatest affinity for IL18 with a rapid on-rate, a slow off-rate and a dissociation constant (kDa) of 399 pM. The two other isoforms with an incomplete immunoglobulin domain are unable to neutralise IL18 [2] .

ALTnames :

rHuIL-18BP; Tadekinig-alfa; IL18BP

Purity :

Greater than 95% as determined by reducing SDS-PAGE.

Buffer :

Lyophilized after extensive dialysis against PBS.

Storage :

Room temperature in continental US; may vary elsewhere.

more info or order :

MedChem Express LLC product webpage