protein

BMP-1, Human (His)

HY-P72106

50 μg; 5 μg; 20 μg; 10 μg

345; 70; 180; 115 USD

BMP-1, Human (His)

Protein

E. coli

50 μg; 5 μg; 20 μg; 10 μg

345; 70; 180; 115 USD

Bone morphogenetic protein 1 (BMP-1) also known as metalloprotease, belonging to the BMP-1/tolloidlike proteinases (BTP) family [1] [2] . BTPs are known to be involved in the control of muscle growth and homeostasis and in wound healing and tissue repair, and BMP-1 is a signature extracellular matrix (ECM) proteins associated with the high metastatic potential of breast tumors [3] . BMP-1 regulates morphogenesis by processing precursors to mature functional extracellular matrix (ECM) proteins and several growth factors including TGFβ, BMP2, BMP4 and GFD8 [4] . BMP1 is the dominant C-proteinase in postnatal lung fibroblasts and mediates cleavage of COOH-terminal propeptide of type I procollagen (CICP) with the main action site of extracellular space [1] . BMP1 maintains appropriate levels of procollagen I and its activated products, acts as an essential part for maintaining periodontal homeostasis and normal cementum formation [2] . The cleavage of thrombospondin-1 (TSP-1), an ECM protein classified as “matricellular” for its ability to regulate cell-matrix interactions, results BMP-1 overexpression. However BMP-1 can both trigger the disruption of cell adhesion and stimulate TGF-β signaling in TSP-1-rich microenvironments, which promote the differentiation of primary human keratocytes into myofibroblasts [3] . Thereby, BMP1 participates in several developmental and physiological processes such as cartilage and bone formation, muscle growth and homeostasis [2] [3] . Mutations of BMP1 gene cause osteogenesis imperfecta in human, a bone disorder characterized by brittle bones that are prone to fracture, or phenotypes of periodontal disease and skin fragility in mice [3] . BMP1-3 is a novel systemic regulator of bone repair. BMP1-3 isoform of the BMP-1 gene circulates in the human plasma and enhances bone healing. In vitro BMP1-3 increases the expression of collagen type I and osteocalcin in MC3T3-E(1) osteoblast like cells, and enhances the formation of mineralized bone nodules from bone marrow mesenchymal stem cells [4] . BMP-1 is widely found in different animals, while the sequence in human is highly similar with rat (96.54%), and mouse (96.34).

>98%

Lyophilized from a 0.2 μm solution of Tris-based buffer, 50% Glycerol.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage.