protein

IL-17F Protein, Human

HY-P7209

10 μg

160 USD

IL-17F Protein, Human

proteins

E. coli

10 μg

160 USD

377622343

IL-17F is an inflammatory homodimeric cytokine that induces many proinflammatory cytokines and chemokines. IL-17F also induces antimicrobial peptides. IL-17F plays a protective role in colon cancer development and can be used for the research of autoimmune diseases, infection and cancer [1] [2] . IL-17F Protein, Human is a recombinant human IL-17F protein and is expressed in E. coli. It consists of 133 amino acids (R31-Q163).

Human

Interleukin-17F (IL-17F) belongs to the IL-17 cytokine family. IL-17F is expressed in activated CD4 T cells, activated monocytes, basophils and mast cells. IL-17F can be produced by differentiated TH17 cells, lamina propria T cells, memory CD4 + T cells, γδ T cells and NKT cells [1] . The human IL-17F shares 55.90% amino acid sequence identity with mouse and 57.14% identity with rat. IL-17F is an inflammatory cytokine that induces many proinflammatory cytokines and chemokines, including TGF-β, IL-2, ICAM1, GM-CSF, CCL2, CCL7, TSLP, MMP13, IL-6 and CXCL1. IL-17F also induces antimicrobial peptides including hBD-2, S100A7, S100A8 and S100A9 with IL-22 and can synergize with IL-23 in human eosinophils to promote the production of IL-1β and IL-6. IL-17F is a homodimeric cytokine. IL-17F shares the most similarities with IL-17A (50% homology) and can be produced as an IL-17AF heterodimer. IL-17A, IL-17F and IL-17A/F use the same receptor complex: IL-17RA and IL-17RC heterodimer. They trigger qualitatively similar signaling pathways, and IL-17F exhibits the lowest biological activity. IL-17F shows about 100–1000 times lower affinity to the IL-17RA subunit than IL-17A, and does not compete with IL-17A binding to IL-17RA [1] [2] . IL-17F plays a protective role in colon cancer development and can be used for the research of autoimmune diseases, infection and cancer [1] [3] [4] .

rHuIL-17F; Cytokine ML-1

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized after extensive dialysis against PBS, pH 7.2, with trehalose or 20 mM PB, pH 7.4.

Room temperature in continental US; may vary elsewhere.