protein

Apolipoprotein C-III/APOC3 Protein, Mouse (His-SUMO)

HY-P72082

50 μg

400 USD

Apolipoprotein C-III/APOC3 Protein, Mouse (His-SUMO)

proteins

E. coli

50 μg

400 USD

Apolipoprotein C-III (APOC3) is a component of VLDL and HDL and plays a crucial role in triglyceride homeostasis. Intracellularly, it facilitates the assembly and secretion of VLDL1 for lipid transport. Apolipoprotein C-III/APOC3 Protein, Mouse (His-SUMO) is the recombinant mouse-derived Apolipoprotein C-III/APOC3 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag. The total length of Apolipoprotein C-III/APOC3 Protein, Mouse (His-SUMO) is 79 a.a., with molecular weight of ~24.9 kDa.

Mouse

Apolipoprotein C-III (APOC3) protein is a vital component of both triglyceride-rich very low-density lipoproteins (VLDL) and high-density lipoproteins (HDL) in plasma, playing a multifaceted role in triglyceride homeostasis. Intracellularly, APOC3 facilitates the assembly and secretion of hepatic very low-density lipoprotein 1 (VLDL1), contributing to lipid transport. Extracellularly, it serves to modulate the hydrolysis and clearance of triglyceride-rich lipoproteins (TRLs), impairing their lipolysis by inhibiting lipoprotein lipase and impeding their hepatic uptake through remnant receptors. Structurally, APOC3 is characterized by several curved helices connected via semiflexible hinges, allowing it to wrap tightly around the curved micelle surface and adapt easily to the different diameters of its natural binding partners. This structural flexibility underscores its versatile involvement in lipid metabolism and transport processes.

Apoc3Apolipoprotein C-III; Apo-CIII; ApoC-III; Apolipoprotein C3

Greater than 90% as determined by reducing SDS-PAGE.

Lyophilized from a 0.2 μm solution of 20 mM Tris-HCl, 0.5 M NaCl, 6% Trehalose, pH 8.0.

Room temperature in continental US; may vary elsewhere.