protein

ALOX12 Protein, Human (His)

HY-P72076

5 μg;10 μg;50 μg

156;265;742 USD

ALOX12 Protein, Human (His)

proteins

E. coli

5 μg;10 μg;50 μg

156;265;742 USD

ALOX12 Protein, Human (His) is a recombinant ALOX12 protein with a His tag. ALOX12 encodes arachidonic acid 12-lipoxygenase that acts on different polyunsaturated fatty acid substrates to produce biologically active lipid mediators including eicosanes and lipoxins [1] .

Human

ALOX12 mainly metabolizes arachidonic acid to 12S-hydroperoxyeicosatetraenoic acid (12( S )-HpETE) and further reduces it to 12( S )-HETE by peroxyglutathione. ALOX12 is widely expressed in various cell types. Because ALOX12 has the function of regulating platelet aggregation, cell migration, and tumor cell proliferation, it is mainly involved in the development of diseasessuch as thrombosis, atherosclerosis, and cancer. ALOX12 is involved in the regulation of inflammation and apoptosisand is involved in the development of liver injury through the activation of the NF-kB signaling pathway and Caspase-3. ALOX12 plays an important role in the occurrence and development of diseases.

12 LOX; 12S; lipoxygenase ; 12-lipoxygenase; 12LO; 12S LOX; 12S-lipoxygenase; 12S-LOX; 12S-type; Alox12; Arachidonate 12 lipoxygenase; Arachidonate 12 lipoxygenase, 12S type; Arachidonate 12-lipoxygenase; Arachidonate 12-oxidoreductase; Lipoxin synthase 12-LO; LOG12; LOX12_HUMAN; P-12LO; Platelet 12-LOX; Platelet type lipoxygenase 12 ; platelet-type 12-lipoxygenase; Platelet-type lipoxygenase 12

Greater than 90% as determined by reducing SDS-PAGE.

Lyophilized from a 0.2 μm sterile filtered 10 mM Tris-HCl, 1 mM EDTA, 6% Trehalose, pH 8.0.

Room temperature in continental US;may vary elsewhere.