protein

AHCY Protein, Human (His-SUMO)

HY-P72073

5 μg;10 μg;50 μg

158;269;753 USD

AHCY Protein, Human (His-SUMO)

proteins

E. coli

5 μg;10 μg;50 μg

158;269;753 USD

AHCY Protein, Human (His-SUMO) is a key cellular enzyme to catalyze the breakdown of S-adenosylhomocysteine (AdoHcy) to homocysteine and adenosine. AHCY Protein, Human is a regulator of biological transmethylation in general.

Human

S-Adenosylhomocysteine hydrolase (AHCY) is a key cellular enzyme to catalyze the breakdown of S-adenosylhomocysteine (AdoHcy) to homocysteine and adenosine, preventing its accumulation and subsequent inhibition of methyl transferases (MTs). In case of AHCY deficiency, intracellular distribution and macromolecular organization of AHCY is impaired, thereby disturbing transmethylation processes possibly in all cellular compartments. AHCY deficiency in humans involves serious biochemical aberrations, retarded psychomotor development, myopathy and myelination disorders, and is potentially lethal in early stages of life. The newest findings link AHCY deficiency to hepatocellular carcinoma [1] [2] .

Adenosylhomocysteinase; AdoHcyase; ahcY; S adenosyl L homocysteine hydrolase; S adenosylhomocysteine hydrolase; S-adenosyl-L-homocysteine hydrolase; SAHH; SAHH_HUMAN

Greater than 90% as determined by reducing SDS-PAGE.

Lyophilized from a 0.2 μm solution of 20 mM Tris-HC1, 0.5 M NaCl, 6% Trehalose, pH 8.0.

Room temperature in continental US;may vary elsewhere.