protein

AADAC Protein, Human (His-SUMO)

HY-P72067

20 μg;50 μg

175;385 USD

AADAC Protein, Human (His-SUMO)

proteins

E. coli

20 μg;50 μg

175;385 USD

AADAC, Human (His-SUMO) is an esterase functioning at the endoplasmic reticulum which involved in the hydrolysis of various drugs. AADAC, Human overexpression alters multiple vascular smooth muscle cells properties and decreases murine cardiovascular disease.

Human

Arylacetamide deacetylase (AADAC) is the major enzyme responsible for the hydrolysis of various clinical drugs, such as flutamide, phenacetin, rifamycins, indiplon, prasugrel, and ketoconazole. AADAC is expressed in the human liver and gastrointestinal tract. AADAC is conserved in animal species, including mice, rats, dogs, and monkeys, although mice and rats have multiple Ces1 and Ces2 isoforms. It has been reported that the expression level of dog CES1 and CES2 in the intestine is much lower than that in the liver. AADAC overexpression alters multiple vascular smooth muscle cells properties and decreases murine cardiovascular disease [1] [2] .

AAAD_HUMAN; Aada; Aadac; Arylacetamide deacetylase esterase; ; Arylacetamide deacetylase; CES5A1; DAC

Greater than 90% as determined by reducing SDS-PAGE.

Lyophilized from a 0.2 μm solution of 10 mM Tris-HCl, 1 mM EDTA, 6% Trehalose, pH 8.0.

Room temperature in continental US; may vary elsewhere.