protein

NRROS Protein, Human (Baculovirus, His-Myc)

HY-P72063

5 μg;10 μg;20 μg;50 μg

215;365;620;1095 USD

NRROS Protein, Human (Baculovirus, His-Myc)

proteins

Sf9 insect cells

5 μg;10 μg;20 μg;50 μg

215;365;620;1095 USD

The NRROS protein is a key TGFB1 regulator with crucial effects on microglial function in the nervous system. It activates latent TGFB1 in macrophages and microglia by forming disulfide bonds with LAP, coordinating integrin-dependent TGFB1 activation. NRROS Protein, Human (Baculovirus, His-Myc) is the recombinant human-derived NRROS protein, expressed by Sf9 insect cells , with N-10*His, C-Myc labeled tag. The total length of NRROS Protein, Human (Baculovirus, His-Myc) is 632 a.a., with molecular weight of ~73.5 kDa.

Human

NRROS, a key regulator of transforming growth factor beta-1 (TGFB1), plays a crucial role in microglia function within the nervous system. Its specific requirement for microglial activity involves the activation of latent TGFB1 in macrophages and microglia, accomplished by forming disulfide bonds with the Latency-associated peptide (LAP), the regulatory chain of TGFB1. NRROS orchestrates integrin-dependent activation of TGFB1, leading to highly localized TGF-beta-1 activation with limited spread to neighboring microglia. This localized and selective activation mechanism suggests the precision of LRRC33/NRROS in modulating TGFB1 signaling. Moreover, NRROS indirectly participates in Toll-like receptor (TLR) signaling, inhibiting TLR-mediated NF-kappa-B activation and cytokine production, possibly as a consequence of its role in TGF-beta-1 signaling. NRROS interacts with TGFB1 through disulfide bonds with LAP and engages with TLR2, TLR3, TLR4, TLR9, and potentially other Toll-like receptors, further emphasizing its multifaceted involvement in immune regulation. Additionally, NRROS directly interacts with CYBB/NOX2, highlighting its diverse functional associations.

NRROS; LRRC33; UNQ3030/PRO9833Transforming growth factor beta activator LRRC33; Leucine-rich repeat-containing protein 33; Negative regulator of reactive oxygen species

Greater than 90% as determined by reducing SDS-PAGE.

Lyophilized from a 0.2 μm sterile filtered PBS, 6% Trehalose, pH 7.4.

Room temperature in continental US;may vary elsewhere.