protein

IGF-I/IGF-1 Protein, Rat

HY-P7203

2 μg;10 μg;50 μg;100 μg

30;70;140;220 USD

IGF-I/IGF-1 Protein, Rat

proteins

E. coli

2 μg;10 μg;50 μg;100 μg

30;70;140;220 USD

377622338

IGF-I/IGF-1 Protein, Rat has somatomedin activity and ability to potently promote neuronal survival.

Rat

IGF-I (Insulin-like Growth Factor-I) has somatomedin activity. IGF-I stimulates the growth of hypophysectiomized rats in a dose-dependent manner [1] . Circulating IGF-I plays a prominent role in normal growth and development by mediating the indirect effects of growth hormone, with which it has a complex relationship. Delivery of IGF-I to the CNS may be beneficial in the treatment of Alzheimer’s disease or stroke because of IGF-I’s ability to potently promote neuronal survival, rescue hippocampal neurons from β-amyloid induced neurotoxicity, reduce tau phosphorylation, protect cortical neurons against nitric oxide-mediated neurotoxicity, rescue neurons from glucose deprivation and stimulate neurogenesis and synaptogenesis [2] .

rRtIGF-I; Somatomedin C; IGF1; Mechano growth factor

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized after extensive dialysis against PBS or PBS, pH 7.4, 8% trehalose.

Room temperature in continental US; may vary elsewhere.