protein

CD46 Protein, Human (HEK293, hFc)

HY-P72020

2 μg;10 μg;50 μg

35;90;250 USD

CD46 Protein, Human (HEK293, hFc)

proteins

HEK293

2 μg;10 μg;50 μg

35;90;250 USD

CD46 Protein serves as a cofactor for complement factor I, safeguarding cells against complement-induced harm. It aids in sperm-oocyte fusion and acts as a T-cell costimulatory factor, facilitating the formation of T-regulatory 1 cells. These cells secrete interleukin-10, suppressing immune responses and preventing autoimmunity. Pathogens can exploit CD46's immune regulation abilities to induce an immunosuppressive state in T-cells. CD46 Protein, Human (HEK293, hFc) is the recombinant human-derived CD46 protein, expressed by HEK293 , with C-hFc labeled tag.

Human

CD46 Protein acts as a cofactor for complement factor I, protecting cells from complement-mediated injury by cleaving C3b and C4b on host tissue. It also plays a role in sperm-oocyte fusion during fertilization and acts as a costimulatory factor for T-cells, promoting the differentiation of CD4+ cells into T-regulatory 1 cells. These T-regulatory 1 cells suppress immune responses by secreting interleukin-10, thus preventing autoimmunity. In the context of microbial infection, certain viral and bacterial pathogens exploit CD46's immune regulation properties by binding to it and inducing an immunosuppressive phenotype in T-cells.

AHUS2; Antigen defined by monoclonal TRA 2 10; Antigen identified by monoclonal TRA 2 10; CD46; TRA2.10

Greater than 90% as determined by reducing SDS-PAGE.

Lyophilized from a 0.2 μm solution of PBS, 6% Trehalose, pH 7.4.

Room temperature in continental US;may vary elsewhere.