protein

CTLA-4 Protein, Guinea pig (P.pastoris, His)

HY-P71986

10 μg;50 μg

135;380 USD

CTLA-4 Protein, Guinea pig (P.pastoris, His)

proteins

P. pastoris

10 μg;50 μg

135;380 USD

CTLA-4 protein, a potent inhibitory receptor, plays a crucial role in suppressing T-cell responses by binding strongly to its ligands CD80 and CD86, surpassing the affinity of CD28. This heightened affinity allows CTLA-4 to act as a major negative regulator, maintaining immune homeostasis and preventing excessive T-cell activation. The balance between CTLA-4 and its ligands is pivotal for immune regulation. CTLA-4 Protein, Guinea pig (P.pastoris, His) is the recombinant CTLA-4 protein, expressed by P. pastoris , with C-6*His labeled tag. The total length of CTLA-4 Protein, Guinea pig (P.pastoris, His) is 125 a.a., with molecular weight of ~18.0 kDa.

Others

CTLA-4 protein functions as a prominent inhibitory receptor, playing a crucial role in dampening T-cell responses. Its inhibitory action stems from the remarkably strong affinity CTLA-4 exhibits for its natural B7 family ligands, CD80 and CD86, surpassing the affinity of their counterpart stimulatory coreceptor, CD28. By virtue of this heightened affinity, CTLA-4 serves as a major negative regulator in the intricate orchestration of T-cell activation and immune responses. The nuanced balance between stimulatory and inhibitory signals mediated by CTLA-4 and its ligands is pivotal for maintaining immune homeostasis and preventing excessive or aberrant T-cell activation.

Cytotoxic T-lymphocyte associated protein 4; CTLA4

Greater than 90% as determined by reducing SDS-PAGE.

Supplied as a 0.2 μm filtered solution of PBS, pH 7.4.

Shipping with dry ice