protein

IL-15R alpha Protein, Mouse (HEK293, hFc)

HY-P71978

2 μg;10 μg;50 μg;100 μg;500 μg;1 mg

35;78;220;350;1200;1920 USD

IL-15R alpha Protein, Mouse (HEK293, hFc)

proteins

HEK293

2 μg;10 μg;50 μg;100 μg;500 μg;1 mg

35;78;220;350;1200;1920 USD

IL-15R alpha is a high affinity receptor for IL-15 (K d : 100 pM) [1] . IL-15R alpha binds IL-15 and thereby activating the antitumor functions of NK cells and CD8+ T cells [2] . IL-15R alpha plays an important role in memory CD8+ T cell homeostasis and lymphocyte development [3] . IL-15R alpha Protein, Mouse (HEK293, hFc) is a recombinant mouse extracellular region of IL-15R alpha (G33-K205) with a C-Terminal hFc tag, which is produced in HEK293 cells.

Mouse

IL-15R alpha is expressed on various cell types, including lymphocytes, myeloid cells, nonlymphoid and nonhematopoietic cells [4] . IL-15R alpha is down-regulated in Epstein-Barr virus associated gastric cancer (EBVaGC) via promoter hypermethylation [5] . The sequence of amino acids in IL-15R alpha differs in different species. Mouse IL-15R alpha shares IL-15R alpha is required for transporting of IL-15 from the endoplasmic reticulum to the cell surface to bind with β (CD122) and γ (CD132) chains on responding lymphocytes [4] [6] . When binding with IL-15, the complex increases the in vivo half-life of IL-15 and enhances binding affinity of IL-15 with IL-15Rβ/γ in NK cells and CD8+ T cells. Thus, the signal transmission improves proliferation and antitumor activities of NK cells and CD8+ T cells [2] . Moreover, IL-15R alpha on the cancer cell surface induces the malignant phenotype, such as augmented cancer cell growth, migration and invasion, and decreased apoptosis [5] . IL-15R alpha mediates immune responses, and is important for lymphocyte activation and proliferation, NK cell survival and proliferation [7] . IL-15R alpha binds with IL-15 and activates the antitumor functions of NK cells and CD8+ T cells, and is also important in memory CD8 T cell homeostasis and lymphocyte development [2] [3] .

Il15ra; Interleukin-15 receptor subunit alpha; IL-15 receptor subunit alpha; IL-15R-alpha; IL-15RA; CD antigen CD215; Soluble interleukin-15 receptor subunit alpha; sIL-15 receptor subunit alpha; sIL-15R-alpha; sIL-15RA;

Greater than 90% as determined by reducing SDS-PAGE.

Lyophilized from a 0.2 μm solution of 20 mM PB, 150 mM NaCl, pH 7.4, 8% trehalose.

Room temperature in continental US; may vary elsewhere.