protein

GRO-gamma/CXCL3 Protein, Human (CHO)

HY-P7192

10 μg;50 μg

115;320 USD

GRO-gamma/CXCL3 Protein, Human (CHO)

proteins

CHO

10 μg;50 μg

115;320 USD

377622328

CXCL3 is a chemoattractant for neutrophils and belongs to CXC chemokine subfamily. CXCL3 is a secreted growth factor that signals through its cognate receptor CXCR2. CXCL3 is involved in many immune responses including wound healing, cancer metastasis, and angiogenesis [1] [2] . GRO-gamma/CXCL3 Protein, Human (CHO) is produced in CHO cells, and consists of 73 amino acids (A35-N107).

Human

CXCL3 is also known as MIP-2 beta, or DCIP-1 in mouse, CINC2 in rat, and GRO-gamma in humans. CXCL3 is a member of the CXC chemokine subfamily, and it is subclassified as a Glu-Leu-Arg (ELR+) CXC chemokine. CXCL3 is originally identified in the supernatants of melanoma cell lines in culture, and is referred to as GRO (growth-related oncogene) [1] . Previous studies have reported that CXCL3 is produced by macrophages, osteoblasts, airway epithelium, dendritic cells, synovial fibroblasts, and cancers [2] . The amino acid sequence of human CXCL3 protein has low homology between mouse and rat CXCL3 protein. CXCL3 plays an important role in leukocyte chemotaxis, angiogenesis, tumorigenesis, and cell invasion. CXCL3 exerts its functions through a number of signaling pathways including p38 MAPK, ERK1/2 MAPK and JAK2/STAT3 etc., by activating CXCR2 receptor. CXCL3 is highly expressed during the number of tumorous conditions including melanoma, prostate, colorectal, aggressive breast cancer tumors, hepatocellular carcinoma (HCC) and also during hepatic injury and inflammation [3] [4] . The cancer types affected by the action of CXCL3 (along with CXCL1 and CXCL2) include prostate cancer, pancreatic cancer, melanoma, lung cancer, hepatocellular carcinoma, and gastric cancer [1] . CXCL3 facilitates adipogenic differentiation through ERK- and JNK-induced induction of c/ebpb and c/ebpd by autocrine/paracrine manners in adipocytes [2] . Furthermore, CXCL3 is also associated with vascular invasion and tumor capsule formation [3] . CXCL3 plays a role in asthma severity and asthmatic airway remodeling [5] .

rHuGRO-γ/CXCL3; C-X-C motif chemokine 3; MIP2-beta

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized after extensive dialysis against PBS.

Room temperature in continental US; may vary elsewhere.