GRO-beta/CXCL2 Protein, Rat | MedChem Express LLC HY-P7191 product information

product summary

company name :

MedChem Express LLC

product type :

protein

product name :

GRO-beta/CXCL2 Protein, Rat

catalog :

HY-P7191

quantity :

10 μg;50 μg

price :

140;390 USD

more info or order :

MedChem Express LLC product webpage

product information

Catalog Number :

HY-P7191

Product Name :

GRO-beta/CXCL2 Protein, Rat

Product Type :

proteins

Host Species :

E. coli

Size :

10 μg;50 μg

List Price :

140;390 USD

list of Pubmed id :

377622327

Product Description :

CXCL2, also called Gro-beta or MIP-2, is a pro-inflammatory cytokine with chemotactic activities on neutrophils. CXCL2 is produced by activated monocytes and neutrophils and expressed at sites of inflammation. CXCL2 is involved in many immune responses including wound healing, cancer metastasis, and angiogenesis [1] [2] . GRO-beta/CXCL2 Protein, Rat is produced in E. coli, and consists of 69 amino acids (A32-N100).

SpeciesSummary :

Rat

Background :

CXCL2 is a chemokine induced by endotoxin and serves as an extremely potent chemo-attractant for neutrophils, acting as a crucial inflammatory mediator. CXCL2 could be produced by multiple, different cell types, including macrophages and cancer cells. CXCL2 is involved in cancer metastasis, angiogenesis, and wound healing [1] [4] [5] . The amino acid sequence of human CXCL2 protein has low homology between mouse and rat CXCL2 protein. CXCL2 is 90% identical in amino acid sequence as a related chemokine, CXCL1. The gene for CXCL2 is located on human chromosome 4 in a cluster of other CXC chemokines. CXCL2 binds to the G-protein coupled receptor CXCR2 (IL-8RB) expressed on macrophages, neutrophils, and epithelial cells and its classical function is to act as chemotactic factors attracting neutrophils to sites of injury [2] [3] . In enterocytes, LPS induces CXCL2 expression and promotes migration of neutrophils in a model of platelet-activating factor induced shock and bowel injury. In acute lung injury, CXCR2 ligands, including CXCL1/2/3, have chemotactic effects for polymorphonuclear leukocytes [4] . CXCL2 could provoke a dose-dependent increase of colorectal tumor cell migration in vitro. Further, according to Bachmeier et al., CXCL-1 and −2 silencing could down-regulate several metastasis-promoting genes and inhibit the metastatic potential of breast cancer cells [5] .

ALTnames :

rRtGRO-β/CXCL2; MIP-2; CINC-3; C-X-C motif chemokine 2

Purity :

Greater than 95% as determined by reducing SDS-PAGE.

Buffer :

Lyophilized after extensive dialysis against PBS.

Storage :

Room temperature in continental US; may vary elsewhere.

more info or order :

MedChem Express LLC product webpage