protein

Interferon tau-1/IFNT1 Protein, Bovine (P.pastoris, His)

HY-P71798

20 μg;50 μg

360;790 USD

Interferon tau-1/IFNT1 Protein, Bovine (P.pastoris, His)

proteins

P. pastoris

20 μg;50 μg

360;790 USD

Interferon tau-1 (IFNT1) serves as an important paracrine hormone that initiates maternal recognition of pregnancy. After interacting with endometrial receptors, possibly type I interferon receptors, IFNT1 blocks estrogen receptor expression and prevents estrogen-induced upregulation of oxytocin receptor expression. Interferon tau-1/IFNT1 Protein, Bovine (P.pastoris, His) is the recombinant bovine-derived Interferon tau-1/IFNT1 protein, expressed by P. pastoris , with N-His labeled tag.

Bovine

Interferon tau-1 (IFNT1) serves as a paracrine hormone pivotal for initiating maternal recognition of pregnancy. Upon interaction with endometrial receptors, likely type I interferon receptors, IFNT1 plays a crucial role in blocking estrogen receptor expression, effectively impeding the estrogen-induced upregulation of oxytocin receptor expression in the endometrium. This mechanism results in the suppression of pulsatile endometrial release of the luteolytic hormone prostaglandin F2-alpha, thereby preventing the regression of the corpus luteum (luteolysis) and facilitating the maintenance of ovarian cyclicity. Additionally, IFNT1, possibly through a direct impact on prostaglandin synthesis, sustains ovarian progesterone secretion, stimulating the endometrial secretion of nutrients necessary for conceptus growth. Notably, IFNT1 exhibits exceptional antiviral and antiproliferative potency, coupled with low cytotoxicity, high antiluteolytic activity, and immunomodulatory properties. A distinctive feature is its lack of virally inducibility in contrast to other interferons.

IFNT1; Interferon tau-1; IFN-tau-1; Antiluteolysin; Trophoblast antiluteolytic protein; Trophoblast protein 1; TP-1; Trophoblastin

Greater than 90% as determined by reducing SDS-PAGE.

Lyophilized after extensive dialysis against solution in 20 mM Tris-HCl, 0.5 M NaCl, 6% Trehalose, pH 8.0.

Room temperature in continental US; may vary elsewhere.