protein

CHGA Protein, Human (P.pastoris, His)

HY-P71727

5 μg;10 μg;50 μg

75;125;350 USD

CHGA Protein, Human (P.pastoris, His)

proteins

P. pastoris

5 μg;10 μg;50 μg

75;125;350 USD

CHGA protein robustly inhibits glucose-induced insulin release from the pancreas, functioning as a non-competitive nicotinic cholinergic antagonist. It inhibits catecholamine release, displays antibacterial activity, induces mast cell responses, and scavenges free radicals. CHGA may also regulate cardiac function and blood pressure. CHGA Protein, Human (P.pastoris, His) is the recombinant human-derived CHGA protein, expressed by P. pastoris , with N-His labeled tag. The total length of CHGA Protein, Human (P.pastoris, His) is 439 a.a., with molecular weight of ~50.9 kDa.

Human

CHGA protein exerts a strong inhibitory effect on glucose-induced insulin release from the pancreas. It functions as a non-competitive nicotinic cholinergic antagonist, inhibiting catecholamine release from chromaffin cells and noradrenergic neurons. Additionally, CHGA displays antibacterial activity against both Gram-positive (S. aureus and M. luteus) and Gram-negative bacteria (E. coli and P. aeruginosa). Moreover, it has the capacity to induce mast cell migration, degranulation, and the production of cytokines and chemokines. Furthermore, CHGA acts as a potent scavenger of free radicals in vitro and may play a role in the regulation of cardiac function and blood pressure.

beta Granin; catestatin; CgA; CHG A; ChromograninA; ER-37; SPI; vasostatin 2; Vasostatin; Vasostatin I; Vasostatin II; vasostatin-2

Greater than 90% as determined by reducing SDS-PAGE.

Lyophilized after extensive dialysis against solution in 20 mM Tris-HCl, 0.5 M NaCl, 6% Trehalose, pH 8.0.

Room temperature in continental US; may vary elsewhere.