protein

QPCT Protein, Mouse (HEK293, His)

HY-P71670

20 μg;50 μg;100 μg

350;665;1060 USD

QPCT Protein, Mouse (HEK293, His)

proteins

HEK293

20 μg;50 μg;100 μg

350;665;1060 USD

The QPCT protein plays a key role in pyroglutamyl peptide biosynthesis and exhibits substrate preference for N-terminal glutamine residues while showing specificity for residues near the N-terminus. Notably, its catalytic activity is independent of chain length beyond the second residue, emphasizing the importance of QPCT in the precise biosynthesis of pyroglutamyl peptides with diverse N-termini, contributing to various biological background. QPCT Protein, Mouse (HEK293, His) is the recombinant mouse-derived QPCT protein, expressed by HEK293 , with N-His, N-Myc labeled tag.

Mouse

The QPCT protein plays a pivotal role in the biosynthesis of pyroglutamyl peptides, exhibiting a preference for substrates with an N-terminal glutaminyl residue while displaying a bias against adjacent acidic and tryptophan residues. Notably, its substrate specificity is more pronounced for the residues proximal to the N-terminal glutaminyl residue, showing a distinctive substrate recognition pattern. Additionally, QPCT demonstrates a lack of significant dependence on chain length beyond the second residue, suggesting that the protein's catalytic activity is less influenced by elongation beyond this point. This selectivity and flexibility in substrate recognition highlight QPCT's significance in the precise biosynthesis of pyroglutamyl peptides, contributing to the diverse array of peptides with pyroglutamylated N-termini in various biological contexts.

Qpct; Glutaminyl-peptide cyclotransferase; EC 2.3.2.5; Glutaminyl cyclase; QC; Glutaminyl-tRNA cyclotransferase

Greater than 90% as determined by reducing SDS-PAGE.

Lyophilized after extensive dialysis against solution in 20 mM Tris-HCl, 0.5 M NaCl, 6% Trehalose, pH 8.0.

Room temperature in continental US; may vary elsewhere.