protein

6Ckine/CCL21B Protein, Mouse

HY-P7167

10 μg;50 μg;100 μg

160;420;756 USD

6Ckine/CCL21B Protein, Mouse

proteins

E. coli

10 μg;50 μg;100 μg

160;420;756 USD

377622303

6Ckine/CCL21B Protein, Mouse is a homeostatic lymphoid chemokine that contributes to the entry of T cells and dendritic cells into the lymphoid T-zone. It acts through chemokine receptors CCR7 and CXCR3 to promote fibrogenic and inflammatory cytokine production. Exodus-2/CCL21 Protein, Mouse  is a recombinant mouse 6Ckine/CCL21B (S24-G133) expressed by E. coli [1] .

Mouse

CCL21, also known as exodus-2 and secondary lymphoid chemokine (SLC), is a small cytokine belonging to the CC chemokine family and is located on chromosome 9 in the human genome. It binds to glycosaminoglycan (GAG) and is anchored to the surface of endothelial cells. As a chemokine, CCL21 inhibits hematopoiesis and stimulates chemotaxis, and is chemotactic in vitro for thymocytes and activated T cells, but not for B cells, macrophages or neutrophils. At the same time, CCL21 is a potent stimulator of T cell migration and adhesion, binding to the glycoprotein PSGL-1 on T cells to promote the migration of T cells to secondary lymphoid organs. CCL21 can act through chemokine receptors CCR7 and CXCR3. Among them, CCR7 is a GPCR that is normally expressed by T cell subsets central memory cells, thymic T cells, B cells, mature DCs and other rare cell subsets. ccl21 can function as a microglia activator in the CNS and is expressed exclusively in endangered or mechanically damaged neurons [1] [2] .

6Ckine; CCL21B; Beta-chemokine exodus-2;

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized after extensive dialysis against 20 mM PB, pH 7.4-8.0, 150 mM NaCl.

Room temperature in continental US; may vary elsewhere.