protein

Exodus-2/CCL21 Protein, Human

HY-P7166

2 μg;10 μg;50 μg;100 μg;500 μg;1 mg

48;140;380;650;1500;2200 USD

Exodus-2/CCL21 Protein, Human

proteins

E. coli

2 μg;10 μg;50 μg;100 μg;500 μg;1 mg

48;140;380;650;1500;2200 USD

377622302

Exodus-2/CCL21 Protein, Human is a homeostatic lymphoid chemokine that contributes to the entry of T cells and dendritic cells into the lymphoid T-zone. It acts through chemokine receptors CCR7 and CXCR3 to promote fibrogenic and inflammatory cytokine production. Exodus-2/CCL21 Protein, Human  is a recombinant human Exodus-2/CCL21 (S24-P134) expressed by E. coli [1] .

Human

CCL21, also known as exodus-2 and secondary lymphoid chemokine (SLC), is a small cytokine belonging to the CC chemokine family and is located on chromosome 9 in the human genome. It binds to glycosaminoglycan (GAG) and is anchored to the surface of endothelial cells. As a chemokine, CCL21 inhibits hematopoiesis and stimulates chemotaxis, and is chemotactic in vitro for thymocytes and activated T cells, but not for B cells, macrophages or neutrophils. At the same time, CCL21 is a potent stimulator of T cell migration and adhesion, binding to the glycoprotein PSGL-1 on T cells to promote the migration of T cells to secondary lymphoid organs. CCL21 can act through chemokine receptors CCR7 and CXCR3. Among them, CCR7 is a GPCR that is normally expressed by T cell subsets central memory cells, thymic T cells, B cells, mature DCs and other rare cell subsets. ccl21 can function as a microglia activator in the CNS and is expressed exclusively in endangered or mechanically damaged neurons [1] [2] .

rHuExodus-2/CCL21; C-C motif chemokine 21; SLC; SCYA21

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized from a 0.2 μm filtered solution of 20 mM PB, 150 mM NaCl, pH 7.4.

Room temperature in continental US; may vary elsewhere.